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Survey for Assessment of Medical Need for PDD/FGR with 5-ALA in UTUC

With this survey we like to evaluate the potential use of 5-ALA in the urinary tract to:

 

1.    detect tumor margins and treatment efficacy (Fluorescence guided ablation)

2.    identification of additional lesions (diagnosis and follow-up)

 

We look forward to your feedback. Thank you very much!

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How would you evaluate the clinical need in UTUC that may be solved by fluorescence detection using 5-ALA?

1 - Not needed, 10 - Highly supportive

How would you evaluate the potential benefit of systemic 5-ALA application over topical installation in bladder?

1 - No Benefit, 10 - Great Benefit
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Is it important to visualize the tumor with fluorescence agents to detect more effected tissue than under white light alone? For Renal Pelvis

1 - Not important, 10 - Very important

For Ureters

1 - Not important, 10 - Very important
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Is there a medical need to visualize the urinary tract from the renal pelvis through the bladder?

1 - No medical need, 10 - High medical need
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How do you follow up UTUC lesions to monitor for recurrence?

If "Other", please provide information.
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Do you treat with ablation?

Do you have any issues with visualization while ablating?

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How often do you do follow-up in low-risk and high-risk tumor patients?

LOW RISK

First FU after ... months:

Second FU after ... months:

HIGH RISK

First FU after ... months:

Second FU after ... months:
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What tools do you use for follow-up in low-risk and high-risk tumor patients?

Low Risk (e.g., endoscopy, endoscopy with CT, …)

High risk (e.g., endoscopy, endoscopy with CT; …)
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Do you feel that MRI/CT is adequate for detection of small lesions?

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Do you have experience with fluorescence detection of tumor lesions by ICG (Indocyanine Green) in combination with white light?

Why or why not? Price situation? Please provide comment:

Do you have experience with fluorescence detection of tumor lesions by Cysview/Hexvix (hexaminolevulinate HCL) in combination with white light?

Why or why not? Price situation? Please provide comment:
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Do you use narrow band imaging or near infrared imaging for any of the following indications/regions?

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Do you access both the ureter and renal pelvis with the same device?

Which cystoscope manufacturers do you work with?

Do you also utilize flexible cytoscopes (ureteroscpes) within the urinary bladder for detection, or do you only use them in ureter/renal pelvis areas?

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How would you evaluate the clinical need in UTUC* that may be solved by fluorescence detection using 5-ALA. *UTUC = Ureter and renal pelvis 1. For diagnosis of lesions

1 - Not needed, 10 - Highly supportive

2. During and directly after tumor ablation/resection for margin and lesion detection

1 - Not needed, 10 - Highly supportive
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Now please take some time to give us some brief feedback on your thoughts regarding the overall usability and necessity of a systemic 5-ALA-fluorescence detection approach:

Thank you for your participation!


If you have any questions or comments, please feel free to contact us. 

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